Snapshots of acyl carrier protein shuttling in human fatty acid synthase.

ABSTRACT: The mammalian fatty acid synthase (FASN) enzyme is a dynamic multienzyme that belongs to the megasynthase family. In mammals, a single gene encodes six catalytically active domains and a flexibly tethered acyl carrier protein (ACP) domain that shuttles intermediates between active sites for fatty acid biosynthesis¹. FASN is an essential enzyme in mammalian development through the role that fatty acids have in membrane formation, energy storage, cell signalling and protein modifications. Thus, FASN is a promising target for treatment of a large variety of diseases including cancer, metabolic dysfunction-associated fatty liver disease, and viral and parasite infections^2,3. The multi-faceted mechanism of FASN and the dynamic nature of the protein, in particular of the AC

SUBMITTER: Schultz K 

PROVIDER: S-EPMC12058525 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature