Comparative analysis of virulence-associated genes in ESBL-producing <i>Escherichia coli</i> isolates from bloodstream and urinary tract infections.

ABSTRACT: The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) is a global health concern due to the multidrug antimicrobial resistance in extraintestinal pathogenic E. coli (ExPEC). ExPEC causes severe infections such as bloodstream infections, meningitis, and sepsis. Uropathogenic E. coli (UPEC), a subset of ExPEC, is responsible for urinary tract infections (UTIs), ranging from asymptomatic bacteriuria and cystitis to more severe conditions, such as pyelonephritis, bacteremia, and sepsis (urosepsis). Although ESBL-producing E. coli may have a significant impact on patient outcomes, comparisons of genotype and virulence factors between ESBL-producing and non-ESBL-producing E. coli have not fully elucidated the factors

SUBMITTER: Tanaka M 

PROVIDER: S-EPMC12058657 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature