Bioinformatics analysis of ferroptosis-related biomarkers and potential drug predictions in doxorubicin-induced cardiotoxicity.

ABSTRACT:

Background

Doxorubicin-induced cardiotoxicity (DIC) significantly impacts the survival and prognosis of cancer patients. Ferroptosis is involved in the pathogenesis of DIC, but its specific mechanisms remain unclear. This study aims to explore key genes of ferroptosis in DIC and potential therapeutic drugs using various bioinformatics methods.

Methods

This study obtained the GSE106297 and GSE157282 datasets from the GEO database, conducted differential gene expression screening and GSEA enrichment analysis using R software. Subsequently obtained ferroptosis-related genes from FerrDb V2, Genecards, Geneontology, and GSEA databases, performed GO and KEGG enrichment analysis after intersecting them with the differentially expressed genes using a Venn diagram. Utilized LASSO reg

SUBMITTER: Yu J 

PROVIDER: S-EPMC12058674 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature