Panoramic lead-immune system interactome reveals diversified mechanisms of immunotoxicity upon chronic lead exposure.

ABSTRACT: Lead exposure is of high prevalence, and over a billion people are chronically exposed to alarming level of lead. Human immune system is highly vulnerable to lead, but the underlying mechanism remains unknown. Using single-cell mass cytometry and mass spectrometry-based proteomics, we performed a panoramic survey of lead targets at both cellular and molecular levels in murine immune system upon chronic lead exposure. We produced a single-cell landscape of lead, thiol metabolism and lead-induced toxicity across all immune cell types. We found that immune cells with extreme thiol metabolism are the most sensitive upon chronic lead exposure. It shows that CD4 + T cells and neutrophils are the most sensitive to lead, which is due respectively to a molecular mechanism rooted in their characteri

SUBMITTER: Hong Y 

PROVIDER: S-EPMC12058832 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature