Loss of function of MusaPUB genes in banana can provide enhanced resistance to bacterial wilt disease.

ABSTRACT: Plants deploy a sophisticated defense mechanism against pathogens through pattern recognition receptors (PRRs) and resistance (R) proteins, activating pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). E3 ubiquitin ligases, notably U-box types like PUB22 and PUB23, modulate PTI by suppressing immune responses. The role of MusaPUB22/23 in immunity against Xanthomonas vasicola pv. musacearum (Xvm), the cause of banana Xanthomonas wilt (BXW) in East Africa, was investigated by knocking out these genes in the BXW-susceptible 'Sukali Ndiizi' cultivar. The gene targets used in this study, MusaPUB22 and MusaPUB23, were identified through prior comparative transcriptomics analysis, which revealed their upregulation in susceptible versus resistant genotypes during early infecti

SUBMITTER: Tripathi L 

PROVIDER: S-EPMC12059061 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature