Prominent role of PM10 in the link between air pollution and incident Parkinson's Disease.

ABSTRACT: Air pollution has been associated with Parkinson's Disease (PD) risk, although this relationship remains unclear. We estimated yearly levels of exposure to ten air pollutants (period 2006-2018) in an Italian population cohort, the Moli-sani study (N = 24,325; ≥35 years; 51.9% women), and derived three principal components, testing their associations with incident PD risk over 23,841 participants (213 cases, median(IQR) follow-up 11.2(2.0) years). This revealed a statistically significant association of PC1 (explaining 38.2% of common variance, tagging PM10 levels), independent on sociodemographic, professional and lifestyles covariates (Hazard Ratio [95%CI] = 1.04[1.02-1.07]). The association was confirmed testing average PM10 levels during follow-up (18[13-24]% increase of PD risk per 1 μ

SUBMITTER: Gialluisi A 

PROVIDER: S-EPMC12059118 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature