DNA methylation in peripheral blood leukocytes in late onset Alzheimer's disease.

ABSTRACT:

Background

Chronic systemic inflammation is implicated in Alzheimer's disease (AD) pathogenesis and has measurable effects on blood cells. There is increasing interest in non-invasive diagnostic tools that use blood-based biomarkers for AD, such as DNA methylation. Notably, DNA methylation changes in blood are also linked to systemic inflammation. The evaluation of DNA methylation profiles in peripheral blood leukocytes as potential biomarkers for AD is promising.

Objective

To determine DNA methylation patterns in blood for AD, and to explore specific blood CpG sites that act as surrogates for brain-tissue methylation.

Methods

DNA methylation data from peripheral blood leukocytes of AD patients and controls were obtained from the Gene Expression Omnibus (GSE59685 and

SUBMITTER: Chacon T 

PROVIDER: S-EPMC12059436 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature