Multi-omics investigation of prospective therapeutic targets for type 1 diabetes.

ABSTRACT:

Background

In recent years, the incidence of type 1 diabetes has been rising steadily, positioning its prevention and treatment as a central focus of global public health initiatives. Previous Mendelian randomization (MR) studies have investigated the relationship between proteomics and type 1 diabetes. Consequently, this study aims to identify prospective therapeutic targets for type 1 diabetes through a comprehensive multi-omics analysis.

Methods

This study primarily utilized the MR method, drawing on genetic data from several large-scale, publicly accessible genome-wide association studies. Within this framework, we applied two-sample MR to evaluate the relationship between five omics components and type 1 diabetes. Finally, we conducted various sensitivity analyses and b

SUBMITTER: Zhang YY 

PROVIDER: S-EPMC12059444 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature