M2 macrophages promote IL-10⁺B-cell production and alleviate asthma in mice.

ABSTRACT:

Introduction

B cells have a central regulatory role in various diseases. While macrophages are found in the disease microenvironment and interact with tissue and diverse immune cells, their relationship with B cells remains poorly explored.

Methods

This study used an asthma animal model and macrophage depletion and demonstrated a significant exacerbation of asthma symptoms upon macrophage removal, coupled with a marked reduction in IL-10⁺ B-cell expression.

Results

Further analysis revealed that the macrophages interacting with IL-10⁺ B cells in the asthma microenvironment were of the M2 subtype. Furthermore, our sequencing data indicated a potential mechanism wherein M2 macrophages promote IL-10⁺ B-cell activity through the TGF-β path

SUBMITTER: Yu B 

PROVIDER: S-EPMC12059559 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature