Hyperuricemia and adverse outcomes in patients with cardiorenal syndrome: A nationwide prospective cohort study in China.

ABSTRACT:

Background

Serum uric acid (UA) has been associated with adverse outcomes in patients with heart failure. However, it remains inconclusive whether such association persists in patients with cardiorenal syndrome (CRS).

Methods

In a nationwide prospective cohort from China, 4907 adults hospitalized for heart failure were enrolled. Of them, 1284 had an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² at admission were included in this study. The Cox regression model was employed to evaluate the relationship between UA levels and mortality, major cardiovascular events (MACE), and hospitalization for heart failure (HHF). Additionally, Harrell's concordance index was utilized to assess the incremental value of UA levels in predicting mortality.

Results

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12059691 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature