Development and Biological Assessment of Thiazole-Based Pyridines for Targeted Therapy in Lung Cancer.

ABSTRACT: The study aims to synthesize, characterize, and evaluate a series of novel compounds for their potential anticancer activity targeting the A549 lung cancer cell line. The hydrazonothiazole-based pyridine compounds (2a-2o) were characterized through melting point analysis, ¹H NMR, ¹³C NMR, and high-resolution mass spectrometry (HRMS). Their physicochemical properties were evaluated using in silico tools, and all compounds were found to comply with Lipinski's drug-likeness rule, suggesting favorable drug-like characteristics. Biological activity studies revealed that all synthesized compounds exhibited potent cytotoxicity against the A549 cell line, with several compounds showing greater efficacy than the standard drug, cisplatin. Selectivity indice

SUBMITTER: Nuha D 

PROVIDER: S-EPMC12059926 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature