Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster.

ABSTRACT: The distribution of allelic effects on traits, along with their gene-by-gene and gene-by-environment interactions, contributes to the phenotypes available for selection and the trajectories of adaptive variants. Nonetheless, uncertainty persists regarding the effect sizes underlying adaptations and the importance of genetic interactions. Herein, we aimed to investigate the genetic architecture and the epistatic and environmental interactions involving loci that contribute to multiple adaptive traits using 2 new panels of Drosophila melanogaster recombinant inbred lines (RILs). To better fit our data, we re-implemented functions from R/qtl using additive genetic models. We found 14 quantitative trait loci (QTLs) underlying melanism, wing size, song pattern, and ethanol resistance. By combin

SUBMITTER: da Silva Ribeiro T 

PROVIDER: S-EPMC12060232 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature