Prevalence of <i>Rocahepevirus ratti</i> (rat hepatitis E virus) in humans and rats in China.

ABSTRACT:

Background & aims

Rocahepevirus ratti (rat hepatitis E virus; rHEV) is a ubiquitous pathogen of rats that has recently emerged as a cause of hepatitis in humans. Although several rHEV cases have been detected worldwide, the extent of human exposure to this hepatitis agent is still poorly defined. We conducted a multicenter surveillance study in China examining rHEV exposures in demographically diverse human populations from a One Health perspective.

Methods

In this multicenter cross-sectional study, we used fully validated rHEV IgG enzymatic immunoassays and reverse transcription PCR in 1,199 individuals with (n = 655) or without hepatitis (n = 544) recruited from three centers in China (Hainan, Hong Kong, and Shenzhen). The patient population included both urban and

SUBMITTER: Cui X 

PROVIDER: S-EPMC12060442 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature