Binding of Urinary Human Serum Albumin Fragments to Albumin-Selective Aptamer-Bound Graphene Quantum Dots: Simulation Studies.

ABSTRACT: Microalbuminuria is a key indicator of chronic kidney disease (CKD), resulting from the leakage of albumin into urine. The accuracy of microalbuminuria measurement depends on urine freshness as improper storage and slow processing can lead to protease digestion of albumin. Recently, graphene-based aptasensors have been shown to detect albumin in aged urine samples, suggesting that albumin fragments can still be recognized by these sensors. To date, nine urinary albumin fragments (F1-F9) have been reported. Meanwhile, the graphene quantum dot (GQD) has emerged as a promising material due to its noncytotoxicity, high biocompatibility, and intrinsic fluorescence properties. Its comparable size to aptamers makes it particularly attractive for albumin detection. In this study, molecular dynamic

SUBMITTER: Archapraditkul C 

PROVIDER: S-EPMC12060652 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature