Elevated serum levels of interleukin-18 discriminate Still's disease from other autoinflammatory conditions: results from the European ImmunAID cohort.

ABSTRACT:

Objectives

Systemic autoinflammatory diseases (SAIDs) represent a set of conditions with exaggerated innate immune responses. IL-1β and IL-18 are key cytokines involved in the pathogenesis of some SAID. We aimed to assess the diagnostic value of serum levels of IL-1β, IL-18, their respective inhibitors IL-1Ra and IL-18 binding protein (IL-18BP), and IFN-γ in SAID.

Methods

A cohort of patients with active SAID, including monogenic (mSAID) and genetically undiagnosed SAID (guSAID) from different European countries, with active disease at inclusion, was established. Serum levels of cytokines were measured by immunoassays.

Results

Sera from 53 mSAID, 220 guSAID and 49 controls without inflammatory disease were analysed. Serum levels of total and free IL-18 were significan

SUBMITTER: Girard-Guyonvarc'h C 

PROVIDER: S-EPMC12060884 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature