Heart Rate Variability and Heart Failure with Reduced Ejection Fraction: A Systematic Review of Literature.

ABSTRACT:

Introduction

Autonomic impairment is a hallmark of heart failure with reduced ejection fraction (HFrEF). While there have been studies on general values for each index of heart rate variability (HRV) analysis in HFrEF, a systematic review comprehensively examining representative values in HFrEF is lacking.

Methods

We searched PubMed, Embase, and Cochrane databases to extract studies reporting representative values of HRV metrics in HFrEF.

Results

A total of 470 HFrEF patients from 6 studies were included in the review. In general, time and frequency domains were abnormally lower in HFrEF, portending a worse prognosis. In HFrEF, the mean or median value of the standard deviation of NN interval, root mean square successive difference, pNN50, and low-frequency power/high

SUBMITTER: Nagai M 

PROVIDER: S-EPMC12060912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature