Consensus Recommendations for Hyperpolarized [1-¹³C]pyruvate MRI Multi-center Human Studies.

ABSTRACT: Magnetic resonance imaging of hyperpolarized (HP) [1-¹³C]pyruvate allows in-vivo assessment of metabolism and has translated into human studies across diseases at 15 centers worldwide. Consensus on best practice for multi-center studies is required to develop clinical applications. This paper presents the results of a 2-round formal consensus building exercise carried out by experts with HP [1-¹³C]pyruvate human study experience. Twenty-nine participants from 13 sites brought together expertise in pharmacy methods, MR physics, translational imaging, and data-analysis; with the goal of providing recommendations and best practice statements on conduct of multi-center human studies of HP [1-¹³C]pyruvate MRI. Overall, the group reached consensus on approximatel

SUBMITTER: Punwani S 

PROVIDER: S-EPMC12060990 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature