Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes.

ABSTRACT:

Purpose

The chemokine system is associated with age-related macular degeneration (AMD), shown in previous studies. In this study, we investigate these chemokines and chemokine receptors and their association with treatment response in neovascular AMD (nAMD), and association to intermediate AMD (iAMD).

Methods

In this prospective cohort study, patients with nAMD, iAMD, and healthy controls were included. The initial and 1-year treatment response was evaluated in patients with nAMD. Plasma chemokine concentrations of CCL2, CCL3, CCL4, CCL20, CXCL8, and CXCL10 were measured with immunoassays. Chemokine receptor expression levels of CCR1, CCR2, CCR5, CCR6, CXCR2, CXCR3, and CX3CR1 on circulating T cells and monocytes were measured with flow cytometry. Correlation network analyse

SUBMITTER: Thomsen AK 

PROVIDER: S-EPMC12061063 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature