Cognitive decline in older adults with type 2 diabetes: Unraveling site-specific glycoproteomic alterations.

ABSTRACT: Type 2 diabetes (T2D) is consistently related to an increased risk of cognitive decline and dementia. However, the molecular underpinnings of this association remain poorly understood. In this study, we applied a novel mass spectrometry-based glycoproteomic methodology to profile serum glycoproteins in older adults with T2D, aiming to identify glycopeptiforms associated with cognitive impairment. Our method allowed comprehensive profiling of N glycosylation in addition to the unique ability to profile glycation events on specific amino acid sites. Serum samples from initially cognitively normal older adults with T2D were collected, with participants classified as cognitive decliners (who developed impairment) and non-decliners (who maintained normal cognition over time). We identified sign

SUBMITTER: Levin Y 

PROVIDER: S-EPMC12061096 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature