Immature Citrus unshiu fruit extracts inhibit adipogenesis in 3T3-L1 adipocytes via AMPK and MAPK signaling pathways.

ABSTRACT: In Korea, immature citrus fruits have been extensively explored for their potential utility as functional bio-health materials owing to their various bioactive properties. However, the specific mechanisms by which they exert inhibitory effects on adipogenesis remain unclear. Therefore, this study aimed to examine the anti-obesity effects of 70% ethanol extracts of immature Citrus unshiu fruits and their solvent fractions (n-hexane, ethyl acetate, n-butanol, and water) on 3T3-L1 cells, as well as to explore the underlying molecular mechanisms. Additionally, this study was conducted to identify the bioactive components responsible for the anti-obesity effects. Among the fractions, the hexane fraction exhibited the most potent inhibitory effect on lipid accumulation in 3T3-L1 cells without in

SUBMITTER: Kim MG 

PROVIDER: S-EPMC12061173 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature