Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Although observational research indicates an association between schizophrenia and dementia, it is unclear whether the two are causally related. In order to examine the causal relationship between schizophrenia and five types of dementia (all-cause dementia, Alzheimer's disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies), we performed a bidirectional two-sample Mendelian randomization analysis.

Methods

In this study, pooled statistics of schizophrenia and dementia were obtained from the Large-scale genome-wide association study (GWAS) in individuals of European ancestry. Inverse variance weighted (IVW) was the primary statistical approach used in this Mendelian randomization, to further support our findings, we also used MR-Egger, w

SUBMITTER: Tao F 

PROVIDER: S-EPMC12061177 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature