Integrated Genomic and Phenotypic Characterization of an <i>Mcr-10.1</i>-Harboring Multidrug Resistant <i>Escherichia coli</i> Strain From Migratory Birds in China.

ABSTRACT: Background: The global rise in antibiotic resistance among multidrug resistant (MDR) Gram-negative (GN) bacteria has posed significant health challenges, leading to the resurgence of colistin as a key defense against these bacteria. However, the widespread use of colistin has resulted in the rapid emergence of colistin resistance on a global scale. Ten members of the (mobile colistin resistance) mcr gene family, mcr-1 through mcr-10, have been reported and documented. Currently, bacteria reported to carry the mcr-10.1 gene are sensitive to colistin, but the mechanism underlying the low-level resistance phenomenon mediated by mcr-10.1 remains unclear. Methods: In this study, antimicrobial susceptibility testing (AST) was conducted on Esche

SUBMITTER: Huang R 

PROVIDER: S-EPMC12061519 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature