New therapeutic targets and mechanisms of papillary thyroid carcinoma identified by multi-omics analysis.

ABSTRACT:

Introduction

The treatment of papillary thyroid carcinoma (PTC) presents ongoing challenges, underscoring the need for novel therapeutic targets.

Methods

This study employed proteomic MR analysis, utilizing publicly available data from genome-wide association studies (GWAS) and protein quantitative trait loci (pQTL) studies. We analyzed proteomic data from deCODE and the UK Biobank Protein Project (UKB-PP), along with GWAS data on papillary thyroid carcinoma (PTC) from the Finnish Consortium. This analysis was further supported by eQTL validation and bioinformatics differential analysis to identify potential therapeutic targets for PTC. Additionally, we explored possible downstream mechanisms of the target proteins through mediation analysis.

Results

Our analysis iden

SUBMITTER: Xu J 

PROVIDER: S-EPMC12061824 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature