The relationship between neurofilament light chain and depressive symptoms according to cognitive status.

ABSTRACT:

Introduction

Although recent studies have suggested a positive association between plasma neurofilament light chain (NfL) and depressive symptoms, the moderating effect of cognitive performance on this relationship remains unclear. The aim of this study was to investigate the association between NfL and depressive symptoms in a population of community-dwelling older adults and to determine whether cognitive status could modify this relationship.

Methods

This is a secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT), including 512 individuals (60.2% women) with a median age of 76 years (interquartile range [IQR]: 7) and with available data for plasmatic NfL levels. Depressive symptoms and cognitive status were assessed using the 15-item Geriatric Depression

SUBMITTER: Bellelli F 

PROVIDER: S-EPMC12061844 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature