Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs.

ABSTRACT:

Background

The SLC19 gene family of solute carriers is a family of three transporter proteins with similar structures, of which SLC19A2 and SLC19A3 mediate thiamin transport; HIF is a transcriptionally active nuclear protein that is a key factor activated in hypoxic environments. Myopia is the most common eye disease that damages the visual health of adolescents, and currently, choroidal hypoxia is one of the prevailing doctrines of myopia, as well as the choroid as an ocular nutrient-supporting tissue, in which thiamine may play a role. This study aimed to investigate the process of thiamine changes in choroidal tissue of guinea pigs with negative lens-induced myopia (LIM).

Methods

The right eyes of guinea pigs in the LIM group wore -6.0D lenses to model experimental myopia

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12061867 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature