Chromene flavanones from <i>Dalea boliviana</i> as xanthine oxidase inhibitors: <i>in vitro</i> biological evaluation and molecular docking studies.

ABSTRACT:

Background

Prenylated flavanones represent a structurally diverse class of natural compounds with significant biological potential. Among them, chromene flavanones (CFs) constitute a rare and specialized subgroup with promising therapeutic applications. These molecules have gained attention due to their potential to inhibit xanthine oxidase (XO), a key enzyme involved in oxidative stress-related disorders such as gout and hyperuricemia. Their distinctive structural features, combined with notable bioactivity, make them compelling candidates for further pharmacological exploration. Given their potential relevance, this study focuses on the in vitro and in silico evaluation of three CFs isolated from Dalea boliviana Britton [Fabacea], assessing their capacity to

SUBMITTER: Bedoya Aguirre EN 

PROVIDER: S-EPMC12062022 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature