Overexpression of MMP14 is associated with poor prognosis and immune cell infiltration in colon cancer.

ABSTRACT:

Introduction

Colorectal cancer (CRC) poses a significant risk of recurrence and distant metastases. This study investigated the regulatory role of Matrix metalloproteinase-14 (MMP14) in immune function and its impact on CRC prognosis.

Methods

we performed transcriptome sequencing on tumor and adjacent non-cancerous samples from four pairs of patients diagnosed with colorectal cancer. Single-cell transcriptome data were analyzed to explore MMP14 expression and immune microenvironment changes. mRNA expression profiles and clinical data were retrieved from public databases (TCGA and GEO). The association between MMP14 and pathways as well as immune regulators was analyzed. Co-expression genes of MMP14 relevant to prognosis were identified. A prognostic model was then con

SUBMITTER: Li N 

PROVIDER: S-EPMC12062125 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature