The innexin 7 gap junction protein contributes to synchronized activity in the <i>Drosophila</i> antennal lobe and regulates olfactory function.

ABSTRACT: In the mammalian olfactory bulb (OB), gap junctions coordinate synchronous activity among mitral and tufted cells to process olfactory information. In insects, gap junctions are also present in the antennal lobe (AL), a structure homologous to the mammalian OB. The invertebrate gap junction protein ShakB contributes to electrical synapses between AL projection neurons (PNs) in Drosophila. Other gap junction proteins, including innexin 7 (Inx7), are also expressed in the Drosophila AL, but little is known about their contribution to intercellular communication during olfactory information processing. In this study, we report spontaneous calcium transients in PNs grown in cell culture that are highly synchronous when these neurons are physically connected. RNAi-mediated knockdo

SUBMITTER: Fuenzalida-Uribe N 

PROVIDER: S-EPMC12062127 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature