Peripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages.

ABSTRACT: The motor stage of Parkinson's disease (PD) can be preceded for years by a prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder (RBD), hyposmia, and constipation. Here, we show that multiple stages of idiopathic PD, including the pre-motor prodromal stage, can be stratified according to the inflammatory responses to stimulation of peripheral blood mononuclear cells ex vivo. IFNγ stimulation of isolated monocytes reveals increased stimulation-dependent secretion of TNF, IL-1β, and IL-8 in prodromal PD relative to moderate stage PD. Additionally, T cells stimulated with CD3/CD28 co-stimulatory beads show diminished proinflammatory cytokine secretion in early-moderate PD relative to prodromal. Receiver operating characteristic curves demonstrate that several cy

SUBMITTER: Mark JR 

PROVIDER: S-EPMC12062209 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature