Assessment of the biofilm formation capacities of Staphylococcus aureus strains Newman and Newman D2C in vitro and in vivo.

ABSTRACT: Staphylococcus aureus is a major cause of implant-associated infections (IAIs). The ability of this Gram-positive bacterium to cause IAIs is closely related to its capacity to attach to and to form biofilms on the implant material. Biofilm formation of S. aureus on artificial surfaces is usually mimicked in the laboratory by simple microplate-based in vitro assays and often involves type culture collection preserved laboratory strains such as SA113 (ATCC 35556), Newman (NCTC 8178), and Newman D2C (NCTC 10833, ATCC 25904). The latter two strains are phylogenetically closely related and often inadvertently indicated as strain "Newman" in publications, albeit of the fact that strain Newman D2C harbors among others mutations in the global regulatory loci agr and sae, which strongly impact the

SUBMITTER: Wieland B 

PROVIDER: S-EPMC12062259 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature