Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8⁺ T cells infiltration in non-small cell lung cancer.

ABSTRACT: Tumor-infiltrating CD8⁺ T cells are critical for anti-tumor immunity and positively associated with patient survival. However, the mechanisms governing CD8⁺ T cell infiltration remain incompletely elucidated, particularly those involving circular RNAs (circRNAs). In this study, we characterized circRNA expression profiles in four paired normal and tumor tissues of non-small-cell lung cancer (NSCLC) and identified that circFNDC3B, a circular transcript derived from exons 2 and 3 of the fibronectin type III domain containing 3B (FNDC3B) gene, as significantly upregulated in NSCLC tissues. Mechanistic investigations revealed that circFNDC3B directly binds to transcription factor II-I (TFII-I), forming an RNA-protein complex that competitively disrupts the interaction bet

SUBMITTER: Wei X 

PROVIDER: S-EPMC12062398 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature