Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro.

ABSTRACT: Trifolin exhibits anti-tumor activities; however, its effect on hypertension remains unknown. This study was performed to investigate trifolin's potential therapeutic effects and underlying mechanisms of action on angiotensin II (Ang II)-induced hypertension in mice and Ang II stimulated A7R5 cells. Mice were randomly allocated into six groups: control, Ang II, Ang II + Trifolin (0.1 mg/kg), Ang II + Trifolin (1 mg/kg), Ang II + Trifolin (10 mg/kg), and Ang II + Valsartan (10 mg/kg). The hypertensive mouse model was constructed by infusing Ang II via a micro-osmotic pump (500 ng/kg/min), and trifolin, valsartan, or double distilled water was administered intragastrically once daily for 4 weeks. Blood pressure, vascular function, pathological morphology, and collagen deposition in Ang II in

SUBMITTER: Shen A 

PROVIDER: S-EPMC12062450 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature