MAMDC2-AS1 Induces Cuproptosis in Relapsed and Refractory Multiple Myeloma.

ABSTRACT:

Background

Multiple myeloma is a malignant disorder involving the uncontrolled proliferation of plasma cells in the bone marrow. Prognosis remains poor for individuals with relapsed and refractory multiple myeloma (RRMM), and the underlying mechanisms are yet to be fully understood.

Methods

We collected bone marrow RNA-Seq data from a total of 557 patients with MM from the GEO database (GSE24080) for further analysis, dividing them into relapsed/refractory and control groups. Additionally, we collected bone marrow samples from 57 MM patients to validate the performed RNA-Seq data analysis.

Results

RNA-Seq analysis of patients with RRMM revealed a significant upregulation of genes associated with cuproptosis. Using the LASSO Cox regression method, several long noncodin

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12062513 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature