Arterial Stiffness, Central Blood Pressure, and the Risk of Incident Stroke in Hypertensive Adults.

ABSTRACT:

Background and aims

Whether hypertensive patients with elevated arterial stiffness and central systolic blood pressure (cSBP) are exposed to higher stroke risk is unclear.

Methods

A total of 6663 participants without a history of cardiovascular disease were enrolled in this study. cSBP was measured noninvasively using the A-Pulse CASPro device; carotid-femoral pulse wave velocity (cfPWV) was collected using a Pulse Pen device. The primary outcome was incident stroke.

Results

Over 4.4 years (median), 454 incident strokes occurred (15.92 per 1000 person-years). Compared to the reference group (cSBP < 137 mmHg and cfPWV < 10 m/s), patients with elevated cSBP and cfPWV had a significantly increased risk of incident stroke (HR 1.78 [95% CI 1.39, 2.27]), and were the only g

SUBMITTER: Cao T 

PROVIDER: S-EPMC12062867 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature