Peripheral blood cytokine profiles predict the severity of SARS-CoV-2 infection: an EPIC³ study analysis.

ABSTRACT:

Background

Predicting which patients will develop severe COVID-19 complications could improve clinical care. Peripheral blood cytokine profiles may predict the severity of SARS-CoV-2 infection, but none have been identified in US Veterans.

Methods

We analyzed peripheral blood cytokine profiles from 202 participants in the EPIC³ study, a prospective observational cohort of US Veterans tested for SARS-CoV-2 across 15 VA medical centers. Illness severity was assessed based on the highest level documented during the first 60 days after recruitment. We correlated cytokine levels with illness severity using LASSO logistic regression, random forest, and XGBoost models on a 70% training set and calculated the AUC on a 30% test set.

Results

LASSO regression identifi

SUBMITTER: Li X 

PROVIDER: S-EPMC12063214 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature