Left ventricular unloading during extracorporeal cardiopulmonary resuscitation: a target trial emulation of the ELSO registry.

ABSTRACT:

Background

Patients who undergo extracorporeal cardiopulmonary resuscitation (ECPR) are at risk of left ventricular distention and complications. There is emerging evidence that concurrent mechanical left ventricular (LV) unloading (e.g. an intra-aortic balloon pump, or microaxial left ventricular assist device) may improve survival. Despite this, there are no large, well-conducted studies investigating the impact of LV unloading on outcomes in ECPR.

Methods

We queried the Extracorporeal Life Support Organisation (ELSO) registry between 2020 and 2023, and used an emulated target trial framework to investigate the association between concurrent mechanical left ventricular unloading and outcomes in patients receiving ECPR. We imputed missing data using multiple imputation with

SUBMITTER: Ling RR 

PROVIDER: S-EPMC12063446 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature