Effect of Ketamine on the Bispectral Index, Spectral Edge Frequency, and Surgical Pleth Index During Propofol-Remifentanil Anesthesia: An Observational Prospective Trial.

ABSTRACT:

Background

Ketamine administration during stable propofol anesthesia is known to be associated with an increase in bispectral index (BIS) but a "deepening" in the level of hypnosis. This study aimed to evaluate the association between the effect-site concentration of ketamine (CeK) and 2 electroencephalogram (EEG)-derived parameters, the BIS and spectral edge frequency (SEF 95 ), after the administration of a ketamine bolus. Secondary aims included investigating the BIS and SEF 95 variations with time and changes in the surgical pleth index (SPI).

Methods

We conducted an observational, prospective, single-center study analyzing intraoperative data from 14 adult female patients undergoing breast oncologic surgery. During stable propofol-remifentanil target-controlled infusion

SUBMITTER: Linassi F 

PROVIDER: S-EPMC12063679 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature