Alcohol and substance use differentially impact suicidal ideation in a longitudinal cohort of bipolar disorder.

ABSTRACT:

Background

Across bipolar disorders (BSDs), alcohol and substance use and suicidal ideation (SI) contribute to increased rates of morbidity and mortality. The goal of the present study was to investigate temporal relationships between the intensity/frequency (I/F) of use and impairment related to alcohol and substance use and SI in a longitudinal BSD cohort.

Methods

Participants with BDI (n=565), BDII (n=162), and BD NOS (n=61) were included (median enrollment=72 months). Alcohol and substance use were measured using a modified version of the AUDIT administered every 6 months. SI was measured every 2 months using item 9 from the PHQ-9. Linear mixed effects models tested concurrent associations and Dynamic Structural Equation Models tested prospective associations between alc

SUBMITTER: Smith JL 

PROVIDER: S-EPMC12063688 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature