Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data.

ABSTRACT: The highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b has caused a human outbreak in North America since March 2024. Here, we conducted a serosurveillance study to determine the risk of A(H5N1) clade 2.3.4.4b (2024 cattle H5N1) to general population. In the initial screening of 180 serum specimens encompassing all age groups, 2.2% (4/180) had detectable neutralizing antibody (nAb) titres against reverse genetics-derived 2024 cattle H5N1, with all collected from older adults aged ≥60 years old. Further screening showed that 4.2% (19/450) of adults aged ≥60 years old had detectable nAb titres against the 2024 cattle H5N1. 80% (4/5) of serum specimens with nAb titre of ≥40 had detectable Hemagglutination inhibition (HI) titre, and there was a positive correlation between nAb titr

SUBMITTER: Chen LL 

PROVIDER: S-EPMC12064101 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature