Tau depletion diminishes vascular amyloid-related deficits in a mouse model of cerebral amyloid angiopathy.

ABSTRACT:

Introduction

Tau is essential for amyloid beta (Aβ)-induced synaptic and cognitive deficits in Alzheimer's disease (AD), making its downregulation a therapeutic target. Cerebral amyloid angiopathy (CAA), a major vascular contributor to cognitive decline, affects over 90% of patients with AD. This study explores the impact of tau downregulation on CAA pathogenesis.

Methods

We crossed the Familial Danish Dementia mouse model (Tg-FDD), which develops vascular amyloid, with tau-null (mTau^-/-) mice to generate a CAA model lacking endogenous tau (Tg-FDD/mTau^-/-). Behavioral, electrophysiological, histological, and transcriptomic analyses were performed.

Results

Tau depletion ameliorated motor and synaptic impairments, reduced vascular amyloid depositio

SUBMITTER: Jury-Garfe N 

PROVIDER: S-EPMC12064415 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature