APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.

ABSTRACT:

Background

Maintenance of cerebral blood flow during orthostasis is impaired with aging and associated with cognitive decline, but the effect of the apolipoprotein ɛ4 allele (APOE4) is unknown.

Methods

Older adults (n = 108) (APOE4 carriers, n = 47; non-carriers, n = 61) diagnosed as having normal cognition (NC), mild cognitive impairment (MCI), or Alzheimer's disease (AD) underwent transcranial Doppler ultrasound assessment of middle cerebral artery blood velocity (MCAv) and beat-to-beat mean arterial blood pressure (MAP) during a sit-to-stand transition. Anticipatory and orthostasis-induced MCAv and MAP responses were compared between genotypes and diagnostic classifications.

Results

Cognitively normal APOE4 carriers showed greater anticipatory MCAv increase, greate

SUBMITTER: Palmer JA 

PROVIDER: S-EPMC12064416 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature