Identification and construction of a novel NET-related gene signature for predicting prognosis in multiple myeloma.

ABSTRACT: Neutrophil extracellular traps are essential in the development and advancement of multiple myeloma (MM). However, research investigating the prognostic value with NET-related genes (NRGs) in MM has been limited. Patient transcriptomic and clinical information was sourced from the gene expression omnibus database. Cox regression analysis with a univariate approach was employed to explore the link between NRGs and overall survival (OS). Kaplan-Meier methods were applied to assess variations in survival rates. A nomogram integrating clinical data and predictive risk metrics was crafted using multivariate logistic and Cox proportional risk model regression analyses. Additionally, we investigated the disparities in biological pathways, drug sensitivity, and immune cell involvement, and validat

SUBMITTER: Yan H 

PROVIDER: S-EPMC12064474 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature