CT-based quantification of intratumoral heterogeneity for predicting distant metastasis in retroperitoneal sarcoma.

ABSTRACT:

Objectives

Retroperitoneal sarcoma (RPS) is highly heterogeneous, leading to different risks of distant metastasis (DM) among patients with the same clinical stage. This study aims to develop a quantitative method for assessing intratumoral heterogeneity (ITH) using preoperative contrast-enhanced CT (CECT) scans and evaluate its ability to predict DM risk.

Methods

We conducted a retrospective analysis of 274 PRS patients who underwent complete surgical resection and were monitored for ≥ 36 months at two centers. Conventional radiomics (C-radiomics), ITH radiomics, and deep-learning (DL) features were extracted from the preoperative CECT scans and developed single-modality models. Clinical indicators and high-throughput CECT features were integrated to develop a combined mode

SUBMITTER: Xu J 

PROVIDER: S-EPMC12064543 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature