<i>Vibrio</i> are a potential source of novel colistin-resistance genes in European coastal environments.

ABSTRACT: Colistin is a widespread last resort antibiotic for treatment of multidrug-resistant bacteria. The recent worldwide emergence of colistin resistance (Col-R) conferred by mcr-1 in human pathogens has raised concern, but the putative sources and reservoirs of novel mcr genes in the marine environment remain underexplored. We observed a high prevalence of Col-R, particularly in Vibrio isolated from European coastal waters by using the same cohorts of oysters as bioaccumulators in three sites across Europe. The high sequence diversity found in the mcr/eptA gene family was geographically structured, particularly for three novel eptA gene variants, which were restricted to the Mediterranean (France, Spain) and occurred as a dgkA-eptA operon. The R

SUBMITTER: Saad J 

PROVIDER: S-EPMC12064563 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature