Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naive individuals with Long COVID.

ABSTRACT:

Background

The symptomatic and immune responses to COVID-19 vaccination of people with Long COVID are poorly characterized.

Methods

In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination.

Results

At 12 weeks post-vaccination, self-reported improved health is seen in 10 out of 16 participants, 3 h

SUBMITTER: Grady CB 

PROVIDER: S-EPMC12064684 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature