Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis.

ABSTRACT:

Background

Changes in gut microbiota metabolism might play an important role in the development of some cancers. However, the causal relationships of gut microbiome-related metabolic pathways in chondrosarcomas and the specific pathways affected remain largely unknown.

Methods

We used two-sample bidirectional and multivariate Mendelian randomization (MR) to reveal a causal relationship between the gut microbiota metabolic pathway (GMMP) and chondrosarcoma associated gene 1(CSAG1) via the largest available genome-wide association study (GWAS).

Results

Univariate MR analysis revealed that tetrapyrrole biosynthesis from glutamate, menaquinol 6 biosynthesis, glycogen degradation II, 8-amino-7-oxononanoate biosynthesis, taxadiene biosynthesis, glycolysis and tRNA charging

SUBMITTER: Liu X 

PROVIDER: S-EPMC12065177 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature