Designing a multi-epitope universal vaccine for concurrent infections of SARS-CoV-2 and influenza viruses using an immunoinformatics approach.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and influenza viruses share several conserved epitopes that can be utilized for the development of universal vaccines. Our previous research demonstrated that recombinant M2e-HA2 (Matrix-2 ectodomain-Hemagglutinin subunit 2) proteins derived from influenza elicited an immune response against the virus, suggesting their potential use in universal influenza vaccine formulations. Given the lack of a specific vaccine to address SARS‑CoV‑2 and influenza co-infections, this study aimed to design a universal vaccine using immunoinformatics methodologies.

Methods

In this study, B-cell and T-cell epitopes were identified from the nucleocapsid (N) protein of SARS‑CoV‑2. Additionally, the N-terminal segments of M2e

SUBMITTER: Mohammadipour S 

PROVIDER: S-EPMC12065216 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature