Comparison of inhalation and total intravenous anesthesia on inflammatory markers in microdiscectomy: a double-blind study.

ABSTRACT:

Background

The choice of anaesthetic technique has the potential to exert a significant influence on the perioperative stress response, immune modulation and inflammation which are critical factors in surgical recovery. The primary objective of this study was to compare 24-h postoperative IL-6 levels between patients undergoing lumbar microdiscectomy under TIVA or sevoflurane anesthesia. Secondary outcomes included perioperative changes in CRP, NLR and PLR.

Methods

This prospective, randomised, double-blind study included 40 patients classified as American Society of Anesthesiologists (ASA) I-II and scheduled for elective lumbar disc herniation surgery. Patients were randomly assigned to receive either TIVA with propofol or inhalational anaesthesia with sevoflurane. Interleu

SUBMITTER: Yediyıldız MB 

PROVIDER: S-EPMC12065224 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature