LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration.

ABSTRACT:

Background

Skeletal muscle possesses a robust regenerative capacity and can effectively repair itself following injury. However, research on the metabolic changes during skeletal muscle regeneration in large animals remains relatively limited. Therefore, in this study, we used pigs as a model and applied non-targeted LC-MS/MS metabolomic technology to reveal the metabolic changes during skeletal muscle regeneration, and conducted an in-depth exploration of important signaling pathways, which can provide a reference for further research on the mechanisms promoting skeletal muscle regeneration.

Methods

In this study, we used 18 piglets aged 35 days and weighing 7.10 ± 0.90 kg to construct a skeletal muscle regeneration model. These piglets were randomly divided into three trea

SUBMITTER: Yi L 

PROVIDER: S-EPMC12065226 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature