Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes.

ABSTRACT:

Background

Skin barrier dysfunction and immune activation are hallmarks of inflammatory skin diseases such as rosacea and psoriasis, suggesting shared pathogenic mechanisms. While barrier disruption may trigger or exacerbate skin inflammation, the precise underlying mechanisms remain unclear. Notably, epidermal barrier compromise leads to a marked increase in barrier alarmin expression. Among these, keratin 6A (KRT6A) plays a role in maintaining skin barrier integrity.

Methods

We treated mouse skin and human keratinocytes, with and without KRT6A expression, with LL37/TNF-α and assessed the severity of inflammation. The specific mechanism by which KRT6A promotes skin inflammation was investigated using mass spectrometry and immunoprecipitation assays.

Results

KRT6A exp

SUBMITTER: Chen M 

PROVIDER: S-EPMC12065298 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature